However, this notion has been challenged by the fact that place cells appear before grid cells during development 10, 11. Grid cells provide input to the hippocampus 8 and are assumed to be the primary determinant of hippocampal place cell firing 3, 5, 9. The precise position of the animal can be decoded from the activity of grid cell ensembles 1, 6, where each cell has multiple firing fields forming a characteristic hexagonal pattern spanning the entire surface of the area visited by the animal 7. Neurons in the medial entorhinal cortex (MEC) represent information such as self-location 1, the direction of the animal’s head 2, proximity to geometric borders 3, speed 4, and possibly the distance traveled by the animal 5. Spatially tuned neurons in the hippocampus and entorhinal cortex are key units for navigation and spatial memory. The ability to encode novel environments without compromising old memories are vital for survival and cognitive functions.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |